Minimal-invasive in-vitro chemosensitivity testing

https://www.datarpgx.de/chemo-scale/

Cancer is an extremely heterogeneous disease. Chemotherapies do not respond in the same way in every patient. Chemo-scale uses a blood sample to examine the effectiveness of chemotherapies on an individual patient. The probability of successful therapy can be significantly increased in certain cases, and treatment failure can largely be avoided.

About Chemo-scale

The conventional ‘Standard of Care’ approach does not take into consideration the overall architecture of a particular patient‘s tumour and consequently, patients could suffer due to failed therapies or aggressive relapse. It is, thus, imperative that the characteristics of the tumour are studied comprehensively before deciding the treatment plan, which has to be personalised to individual patients and their disease.

DCG has proven the clinical relevance of chemo-scale with trials comprising more than 5.000 patients.

Chemo-scale is an analysis of tumour cells to provide drug efficacy and resistance guidance for chemotherapy.

With chemo-scale analysis, we minimise the risks of therapy failure for the patient - saving money, reducing 'trail and error' and most importantly, intensifying the attack on the patient's cancer, not the patient.

• Chemo-scale directly tests the effect of chemotherapy / anti-cancer drugs on the patient's tumour cells. It helps to customise the treatment plan according to the sensitivity and resistance patterns of tumour cells.
• With this information, the physician and the patient can choose the most effective chemotherapy from the available options.
• Chemo-scale is performed on cells taken from a fresh biopsy sample of the tumour or circulating tumour-associated cells (C-ETACs) isolated from peripheral blood. A control analysis is included.
• Analysing the chemosensitivity pattern of circulating tumour-associated cells and tumour tissue-derived cells of the same patient, a concordance of 93.7% was observed.

Analysis Unravels

• Results in percentages: Chemo-scale reveals cytotoxic chemotherapy drug efficacy
• Ranking of test results: In the TR the drugs are listed by hierarchy
• Broad range of substances: Analysis is carried out for single drugs and on request also for repurposed drugs, biologicals and drug combinations

Sample collection

Requirements: 20 ml blood in EDTA tubes